Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial
Authors' conclusion
Higher concentrations of antioxidant vitamins during pregnancy increased specific micronutrients and did not impact maternal inflammation and oxidative stress, which may be related to dosing or type of supplementation provided.
Study context
- Population
- Pregnant women with body mass index (BMI) ≥ 30 kg/m² recruited at initial prenatal visit (< 13 weeks gestation)98 completed follow-up
- Participants
- 128 women
- Comparison
- Antioxidant micronutrient supplement vs placebo, both with standard prenatal vitamin
- Interventionn = 64
- Controln = 64reference
- Primary endpoint
- Micronutrient concentrations (vitamin C, E, B6, folate), markers of inflammation (C-reactive protein, interleukin-6, 8, 1β) and oxidative stress (8-epi-PGF2α, malondialdehyde)
- Follow-up
- Baseline, 24-28 weeks and 32-36 weeks
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Vitamin B6 (ln)
β
0.76 nmol/L
95% CI 0.40–1.12
24-28 weeks; higher with intervention
β
0.52 nmol/L
95% CI 0.17–0.88
32-36 weeks; higher with intervention
Secondary outcomes
Maternal and neonatal clinical outcomes · enrollment to delivery
- No differences in maternal or neonatal clinical outcomes by randomization group
Original publication
Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial. Int J Obes (Lond). Published 23 February 2024. doi:10.
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