Substance P and Neurokinin-1 receptor are overexpressed in adamantinomatous craniopharyngioma than in the pituitary gland
Authors' conclusion
These findings, reported here for the first time, suggest a role for SP and NK-1R in pituitary gland and ACP and opens the door to future clinical trials on treatment with NK-1R antagonist drugs in ACP patients.
Study context
- Population
- Human adamantinomatous craniopharyngioma samples compared with healthy pituitary gland samples
- Comparison
- Adamantinomatous craniopharyngioma (ACP) vs healthy pituitary gland
- ACPn = 43
- Outcome
- Existence and distribution of SP and NK-1R expression by immunohistochemistry
Main finding
As reported in the abstract
- Substance P (SP) and NK-1R overexpressed in all ACP more than in pituitary gland samples
- SP widespread in ACP, preferentially nuclear rather than cytoplasmic in tumor cells; glial reaction areas and endothelial cells also express SP preferentially in nuclei
- NK-1R expressed mainly in glial reaction (nuclei and membranes of inflammatory cells, less in cytoplasm) and in endothelial cells and fibroblasts of ACP neovessels
- Tumor cells did not show significant NK-1R expression
Original publication
Substance P and Neurokinin-1 receptor are overexpressed in adamantinomatous craniopharyngioma than in the pituitary gland. Pituitary. Published 26 December 2024. doi:10.
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