Structured nutritional management of insulin resistance in women with Polyendocrine Metabolic Ovarian Syndrome (PMOS) (formerly PCOS) receiving GLP-1RA therapy
Authors' conclusion
This is not weight-centric care. It is metabolic restoration-focused care - encompassing HOMA-IR trajectory, lean mass and micronutrient status together - supporting a role for the clinical nutritionist within GLP-1RA prescribing pathways for women with PMOS.
Study context
- Population
- Women with PMOS (formerly PCOS) receiving GLP-1RA therapy
- Outcome
- Weight, androgens and fasting insulin
Main finding
As reported in the abstract
- GLP-1RAs produced consistent reductions in weight, androgens and fasting insulin
Further findings
Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)
- HOMA-IR outcomes remained heterogeneous across trials, with gains reversing after treatment withdrawal
Nutritional consequence of appetite suppression
- Inadequate protein intake and progressive micronutrient depletion - compounding pre-existing PMOS-specific deficits
Original publication
Structured nutritional management of insulin resistance in women with PMOS (formerly PCOS) receiving GLP-1RA therapy. Diabetes Res Clin Pract. Published 13 November 2026. doi:10.
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