Stroke outcomes in patients with obesity undergoing recanalization therapy
Main finding · Poor functional outcomes (mRS 3-6)Result — go to the resultAdjusted odds ratio 2.82 95% CI 1.16–6.88Authors' conclusion
In this prospective cohort study, obesity was associated with worse functional outcomes at 3 months with a persistent trend at 1 year in AIS patients undergoing recanalization therapy. These findings provide exploratory, preliminary, hypothesis-generating evidence against the theory of the "obesity paradox" and warrant confirmation in larger cohorts.
Study context
- Population
- Acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) and/or endovascular therapy (EVT) who were functionally independent prior to AIS (mRS 0–2), 01/2016 to 09/2021; median age 70 years, 65% male, median NIHSS 5 [interquartile range 3–11]patients enrolled · IVT 153 · EVT 56 · IVT + EVT 62
- Participants
- 271 participants
- Exposure
- Obesity, when compared to normal weight
- NORMAL WEIGHTn = 96reference
- OVERWEIGHTn = 113
- OBESITYn = 62
- Outcome
- Poor functional outcomes (mRS 3-6)
- Follow-up
- Three months
Methodological detailstwo comprehensive Stroke Centers in Switzerland, logistic regression adjusted for age and sex
- Two comprehensive Stroke Centers in Switzerland
- Logistic regression adjusted for age and sex
Main finding
As reported in the abstract
Adjusted odds ratio
2.82
95% CI 1.16–6.88
P = 0.03
By group
OBESITYvs NORMAL WEIGHT
aOR 2.82 (95% CI 1.16–6.88); P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Poorer outcomes · 1 yearOBESITYvs NORMAL WEIGHTTrend | 2.50 (0.98–6.34) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Functional outcome, normal weight vs overweight
- There was no difference between patients with normal weight and those who were overweight
Original publication
Stroke outcomes in patients with obesity undergoing recanalization therapy. Int J Obes (Lond). Published 12 November 2026. doi:10.
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