Stratification of Atherosclerosis based on Plasma Metabolic States
Authors' conclusion
Our results provide a global view of atherosclerosis risk states using plasma metabolomics.
Study context
- Population
- Adults with body mass index (BMI) ≥ 27 kg/m² at a university hospital in the Netherlands
- Participants
- 302 adults
- Outcome
- Atherogenic state (continuous spectrum from plasma metabolomics and clinical metadata)
Methodological detailssingle-centre, plasma metabolomics, validation cohorts
- Single-centre
- Plasma metabolomics
- Validation cohorts
Main finding
As reported in the abstract
- Wide variation of atherogenic states within each clinical condition (e.g. metabolically healthy obesity, metabolic syndrome); spectrum generalizable
- Metabolites associated with atherogenic state regardless of condition, e.g. gamma-glutamyl-glutamic acid and homovanillic acid sulfate
- Pathways highlighted: phenylalanine and tyrosine catabolism; estrogen and phenylpropanoid biosynthesis
Observational data: associations, not effects.
Further findings
Validation cohorts
- Variation in atherogenic states confirmed in healthy subjects before visible plaques; associated metabolites also associated with future CVD
Original publication
Stratification of Atherosclerosis based on Plasma Metabolic States. J Clin Endocrinol Metab. Published 4 December 2023. doi:10.
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