Genetic Risk Scores Identify People at High Risk of Developing Diabetic Kidney Disease: A Systematic Review
Authors' conclusion
This systematic review presents evidence of the utility of GRSs to identify people with diabetes that are at high risk of developing DKD. In practice, a robust GRS could be used at the first clinical encounter with a person living with diabetes in order to stratify their risk of complications. Further prospective research is needed.
Study context
- Population
- People with T1D or T2D; studies of genetic risk scores (GRSs) for predicting diabetic kidney disease (DKD)15 studies
- Outcome
- Association of GRSs with DKD
Methodological detailsCritical Appraisal Skills Programme quality assessment, MEDLINE, Embase, Web of Science and Cochrane Reviews searched June 2022; 400 citations identified
- Critical Appraisal Skills Programme quality assessment
- MEDLINE, Embase, Web of Science and Cochrane Reviews searched June 2022; 400 citations identified
Pooled result
As reported in the abstract
Studies with positive results
7
Studies with mixed results
5
Studies with negative results
3
Most studies with strongest methodological quality reported statistically significant, favourable association of a GRS with ≥1 measure of DKD
n = 9
Original publication
Genetic Risk Scores Identify People at High Risk of Developing Diabetic Kidney Disease: A Systematic Review. J Clin Endocrinol Metab. Published 1 December 2023. doi:10.
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