Peri-renal and renal sinus fat accumulation and diabetic kidney disease in type 2 diabetes: A Japanese cohort study
Main finding · DKDResult — go to the resultHazard ratio 1.96 95 % CI 1.14–3.39Authors' conclusion
The findings demonstrate that renal fat measure, particularly RSFVI, provides incremental predictive value independent of conventional DKD risk variables, suggesting that local renal fat may be a target for early DKD detection and intervention in people with T2D.
Study context
- Population
- Diabetic kidney disease (DKD)-free Japanese adults with T2D; mean age 58 years, 52.6 % male, median diabetes duration 5 years, body mass index (BMI) 25.4 kg/m²DKD-free
- Participants
- 190 adults
- Exposure
- Tertiles of renal fat indices vs BMI, visceral fat area (VFA) and subcutaneous fat area (SFA) for predicting DKD
- Outcome
- Development of DKD
- Follow-up
- median 8.5-year follow-up
Methodological details15-year cohort, CT-measured abdominal and renal fat, tertiles of five adiposity indices
- 15-year cohort
- CT-measured abdominal and renal fat
- Tertiles of five adiposity indices
Main finding
DKD
Hazard ratio
1.96
95 % CI 1.14–3.39
P = 0.016
Tertiles of renal fat indices (PRFVI, RSFVI)vs BMI, VFA and SFA for predicting DKD
HR 1.96 (95 % CI 1.14–3.39); P = 0.016
As reported in the abstract
- Developed DKD
- 53.7 %
- Renal sinus fat volume index (RSFVI) best predictive value for DKD among all indices (AUC)
- 0.769
Observational data: associations, not effects.
Further findings
Correlates of renal fat indices
- Peri-renal fat volume index (PRFVI) correlated with BMI, whereas RSFVI correlated with aging
Original publication
Peri-renal and renal sinus fat accumulation and diabetic kidney disease in type 2 diabetes: A Japanese cohort study. Diabetes Res Clin Pract. Published 25 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →