Statin Use and the Risk of Venous Thromboembolism in Women Taking Hormone Therapy
An erratum to this article was published (JAMA Netw Open, 4 Mar 2024 ↗)
Authors' conclusion
In this case-control study, statin therapy was associated with reduced risk of VTE in women taking HT, with greater risk reduction with high-intensity statins. These findings suggest that statins may reduce risk of VTE in women exposed to HT and that HT may not be contraindicated in women taking statins.
Study context
- Population
- Women aged 50 to 64 years with ≥1 year of continuous enrollment between 2008 and 2019, US commercial claims database20,359 cases · 203,590 controls
- Participants
- 223,949 women
- Comparison
- Hormone therapy (HT) with or without statins vs neither
- Outcome
- Venous thromboembolism (VTE) (diagnostic codes, preceded by ≥12 months without VTE and followed within 30 days by anticoagulation, inferior vena cava filter or death)
Methodological detailscommercially insured claims database, controls matched 10:1 on date and age, conditional logistic regression adjusted for comorbidities
- Commercially insured claims database
- Controls matched 10:1 on date and age
- Conditional logistic regression adjusted for comorbidities
Main finding
As reported in the abstract
VTE
Odds ratio (95% CI)
HT without statinsvs Neither HT nor statins
1.53(1.44–1.63)
HT with statinsvs Neither HT nor statins
1.25(1.10–1.43)
Statins without HTvs Neither HT nor statins
0.89(0.85–0.94)
HT with statinsvs HT without statins18% lower odds
0.82(0.71–0.94)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| VTE, any recent HTvs no recent HTAdjusted models | 1.51 (1.43–1.60) | |
| VTE, current statinvs no current statinAdjusted models | 0.88 (0.84–0.93) | |
| 0.512Odds ratio (log scale) |
Statin intensity (subgroup analysis)
- Greater risk reduction with higher intensity statins
Exposure prevalence
- Recent HT exposure
- 19 558 (8.73%)
- Current statin exposure
- 36 238 (16.18%)
Original publication
Statin Use and the Risk of Venous Thromboembolism in Women Taking Hormone Therapy. JAMA Netw Open. Published 1 December 2023. doi:10.
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