Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort
Authors' conclusion
Almost half of PAs have at least one atypical feature on US. Awareness of the high prevalence of atypical US features could increase the accuracy of US examination and potentially decrease demand for more expensive second-line imaging modalities.
Study context
- Population
- Patients with biochemically proven primary hyperparathyroidism (PHPT); 359 female and 86 male
- Participants
- 445 patients457 parathyroid adenomas (PAs)
- Outcome
- Atypical US features of PAs (size, composition, shape, echogenicity, location, vascular pattern) and main reasons for false negative US
Methodological detailssingle-centre, prospectively maintained database
- Single-centre
- Prospectively maintained database
Main finding
As reported in the abstract
US features of PAs
- Typical ultrasonographic (US) features
- 231 PAs (51%)
- At least one atypical US feature
- 226 (49%)
- Atypical size
- 29%
- Atypical echogenicity
- 19%
- Atypical shape
- 8%
- Atypical location
- 7%
- Atypical composition
- 7%
Observational data: associations, not effects.
Further findings
Initially missed PAs: main reasons for false negative US
- Initially missed PAs
- 122
- Atypical size
- 22.1%
- Atypical location
- 18.8%
- Inexperience (third most common reason)
- 16.3%
Original publication
Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort. J Clin Endocrinol Metab. Published 5 September 2023. doi:10.
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