Sleep duration and timing are prospectively linked with insulin resistance during late adolescence
Authors' conclusion
Insufficient sleep duration and late sleep timing were associated with development of IR over a 2-year period in late adolescence.
Study context
- Population
- Mexico City adolescents in the ELEMENT longitudinal birth cohort, peri-puberty
- Exposure
- Short sleep duration or later sleep timing vs recommended duration or earliest timing
- Outcome
- Development of IR (HOMA-IR categories, puberty-specific cut points)
- Follow-up
- ≈2 years
Methodological detailslongitudinal birth cohort (ELEMENT), two visits ≈2 years apart, 7-day wrist actigraphy, multinomial logistic regression adjusted for age, sex and baseline pubertal status
- Longitudinal birth cohort (ELEMENT)
- Two visits ≈2 years apart
- 7-day wrist actigraphy
- Multinomial logistic regression adjusted for age, sex and baseline pubertal status
Main finding
As reported in the abstract
Development of IR
Each group vs earliest midpointOdds ratio (95% CI)
Latest midpoint
2.63(1.0–6.7)
- ≥1 h below recommendations
- times more likely 2.74 (95% CI 1.0–7.4)
Observational data: associations, not effects.
Further findings
Mediation by adiposity change
- Changes in adiposity over follow-up did not mediate sleep and insulin resistance (IR)
Original publication
Sleep duration and timing are prospectively linked with insulin resistance during late adolescence. Obesity (Silver Spring). Published 27 February 2023. doi:10.
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