Longer time in blood pressure target range improves cardiovascular outcomes among patients with Type 2 diabetes: A secondary analysis of a randomized clinical trial
Primary result · MACEResult — go to the resultHazard ratio 0.54 95 % CI 0.43–0.67Authors' conclusion
Longer TIR is associated with lower cardiovascular risk and may add value as an outcome measure for hypertension control studies among patients with diabetes.
Study context
- Population
- Patients with T2D in the ACCORD trial
- Comparison
- Higher TIR vs TIR 0-22.9 %
- Primary endpoint
- MACE
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Hazard ratio
0.54
95 % CI 0.43–0.67
TIR 61.9-100.0 %vs TIR 0-22.9 %
HR 0.54 (95 % CI 0.43–0.67)
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Stroke | 0.19 (0.10–0.36) | |
| MI | 0.67 (0.51–0.89) | |
| HF | 0.47 (0.33–0.66) | |
| Cardiovascular death | 0.63 (0.42–0.93) | |
| All-cause mortality | 0.70 (0.54–0.91) | |
| 0.10.31310Hazard ratio (log scale) |
Shape and independence of TIR–major adverse cardiovascular events (MACE) association
- Curvilinear association of TIR with MACE, independent of baseline, final SBP, mean SBP or visit-to-visit SBP variability
Original publication
Longer time in blood pressure target range improves cardiovascular outcomes among patients with Type 2 diabetes: A secondary analysis of a randomized clinical trial. Diabetes Res Clin Pract. Published 27 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →