Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997–2017)
Authors' conclusion
Unadjusted fracture rates are higher in patients with diabetes but have decreased between 1997 and 2017 except for vertebral fractures, which increased in all groups. Fracture rates change after age adjustment.
Study context
- Population
- Patients aged ≥18 years with a vertebral, hip, humerus, forearm, foot or ankle fracture, Denmark, 1997–2017
- Exposure
- T1D or T2D vs no diabetes
- Outcome
- Trends in fracture IRs per 10,000 person-years by site; median IRs of first (1997-2001) vs last (2013-2017) 5 years
- Follow-up
- 1997-2017
Methodological detailsDanish hospital discharge data, Poisson models, age-adjusted
- Danish hospital discharge data
- Poisson models, age-adjusted
Main finding
As reported in the abstract
Fracture IRs by site
- Except for foot fractures, fracture incidence rates (IRs) higher in T1D or T2D vs without diabetes
Observational data: associations, not effects.
Further findings
Fracture IRs by diabetes status · 1997–2017
- Except for foot fractures, fracture IRs higher in T1D or T2D vs without diabetes
Hip fracture IRs, change between first (1997-2001) and last (2013-2017) 5 years
- Hip fracture IRs declined by 35.2%, 47.0%, and 23.4% in T1D, T2D, and without diabetes, respectively
Vertebral fracture IRs, change between first and last 5 years · 1997-2001 vs 2013-2017
- Vertebral fracture IRs increased 14.8%, 18.5%, 38.9%, respectively
Age-adjusted IR ratios (IRRs) vs without diabetes
- Age-adjusted IRRs remained elevated in T1D vs without diabetes; IRRs in T2D converged with those without diabetes
Original publication
Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997–2017). Diabetes Care. Published 25 January 2023. doi:10.
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