Single-Cell Analysis of Subcutaneous Fat Reveals Profibrotic Cells That Correlate With Visceral Adiposity in HIV
Authors' conclusion
In PWH, greater VAT volume is associated with a higher proportion of SAT IMs and fibroblasts, and a SAT ECM and inflammatory transcriptome, which is similar to findings in HIV-negative persons with obesity. These data identify SAT cell-type specific changes associated with VAT volume in PWH that could underlie the high rates of cardiometabolic diseases in PWH, though additional longitudinal studies are needed to define directionality and mechanisms.
Study context
- Population
- Persons with HIV on long-term antiretroviral therapy (ART) with a spectrum of metabolic health43 with single-cell RNA sequencing
- Participants
- 92 persons
- Outcome
- Association of SAT cell types and transcriptome with VAT volume
Methodological detailssingle-cell RNA sequencing, bulk RNA sequencing
- Single-cell RNA sequencing
- Bulk RNA sequencing
Main finding
As reported in the abstract
- Higher proportions of subcutaneous adipose tissue (SAT) intermediate macrophages, myofibroblasts and MYOC+ fibroblasts associated with greater visceral adipose tissue (VAT) volume (partial Spearman's correlation adjusted for age, sex, BMI)
- r = 0.34-0.49, P < .05 for all
- VAT volume associated with HOMA2-IR
- P < .001
Observational data: associations, not effects.
Original publication
Single-Cell Analysis of Subcutaneous Fat Reveals Profibrotic Cells That Correlate With Visceral Adiposity in HIV. J Clin Endocrinol Metab. Published 31 May 2024. doi:10.
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