Simplification of the Oral Sodium Loading Test: 2-Day Method Replacing 3-Day Method
Authors' conclusion
This study confirms that the 2-day method can replace the 3-day method in OSLT for a more convenient diagnosis of PA.
Study context
- Population
- Primary aldosteronism (PA) patients (median age 51.5 years, 75% men) and healthy participants (median age 30.5 years, 25% men) undergoing a 3-day oral high-sodium diet, December 2023 to December 2024
- Participants
- 12 vs 12
- Comparison
- Oral sodium loading test (OSLT) day 2 vs day 3
- PAn = 12
- Healthyn = 12
- Outcome
- 24-hour urinary aldosterone, day 2 vs day 3 of OSLT
- Follow-up
- Second and third day of OSLT
Performance
As reported in the abstract
Correlation of 24-hour urinary aldosterone, day 2 vs day 3, PA
r = 0.8322
Correlation of 24-hour urinary aldosterone, day 2 vs day 3, healthy participants
r = 0.9333
Further findings
24-hour urinary sodium after oral sodium loading
- All participants had 24-hour urinary sodium >200 mmol/24 h
Aldosterone-related steroid hormone profile
- No statistically significant difference between the two days, in PA patients or healthy participants
Original publication
Simplification of the Oral Sodium Loading Test: 2-Day Method Replacing 3-Day Method. Endocr Pract. Published 1 July 2025. doi:10.
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