Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC)
Authors' conclusion
Associations between adipokines and cIMT were sex-specific, and metabolic health status influenced the relationships between adipokines and cIMT. These heterogeneities by sex and metabolic health affirm the complex relationships between adipokines and atherosclerosis.
Study context
- Population
- Hispanic adults, Cameron County Hispanic Cohort; mean age 50, 70.8% female
- Participants
- 624 adults
- Outcome
- Association between adipokines (adiponectin, leptin, resistin, LAR, ARI) and cIMT
Methodological detailssex-stratified analyses, fully adjusted linear regression
- Sex-stratified analyses
- Fully adjusted linear regression
Main finding
As reported in the abstract
cIMT, fully adjusted, sex-specific associations
- Interaction by sex for adiponectin, leptin and leptin-to-adiponectin ratio (LAR)
- p < 0.1
- Males: LAR and carotid-intima media thickness (cIMT), β(SE)
- 0.060 (0.016), p = 2.52 × 10-4
- Females: adiponectin and cIMT, β(SE)
- 0.010 (0.005), p = 0.043
- Females: Adiponectin-resistin index (ARI) and cIMT, β(SE)
- - 0.011 (0.005), p = 0.036
Observational data: associations, not effects.
Further findings
cIMT stratified by metabolic health status
- Males, metabolically healthy: LAR and cIMT, β(SE)
- 0.127 (0.015), p = 4.70 × 10-10
- Females, metabolically elevated risk: adiponectin and cIMT, β(SE)
- 0.014 (0.005), p = 0.012
- Females, metabolically elevated risk: ARI and cIMT, β(SE)
- - 0.015 (0.006), p = 0.013
- p for interaction by metabolic health
- < 0.1
- Female-specific associations observed only among the metabolically elevated risk group
Original publication
Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC). Cardiovasc Diabetol. Published 31 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →