Association between the triglyceride glucose (triglyceride-glucose (TyG)) index and the risk of acute kidney injury in critically ill patients with heart failure: analysis of the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Authors' conclusion
The results highlight the TyG index as a robust and independent predictor of the incidence of AKI and poor renal outcome in patients with HF in a critical condition. However, further confirmation of causality necessitates larger prospective studies.
Study context
- Population
- Critically ill patients with heart failure (HF), MIMIC-IV database; 59% male
- Participants
- 1,393 patients
- Exposure
- TyG index quartiles
- Outcome
- Incidence of AKI
Methodological detailsMIMIC-IV database, TyG index quartiles
- MIMIC-IV database
- TyG index quartiles
Main finding
As reported in the abstract
AKI
Incidence of acute kidney injury (AKI) (whole cohort)
82.8%
Observational data: associations, not effects.
Secondary outcomes
Use of renal replacement therapy (RRT) in AKI subset, by TyG index quartile
- Statistically significant differences in RRT use across TyG index quartiles (Kaplan-Meier)
Original publication
Association between the triglyceride glucose (TyG) index and the risk of acute kidney injury in critically ill patients with heart failure: analysis of the MIMIC-IV database. Cardiovasc Diabetol. Published 31 August 2023. doi:10.
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