Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes
Authors' conclusion
The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.
Study context
- Population
- Swedish children at T1D diagnosis, population-based nationwide sample
- Participants
- 3,645 children
- Exposure
- Girls vs boys
- Outcome
- Age at T1D diagnosis
- Follow-up
- At diagnosis
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Autoantibody-positive · at diagnosis
P = 0.002
GADA-positive · at diagnosis
P < 0.001
IAA-positive · at diagnosis · less likely in girls
P = 0.016
- Positive for multiple autoantibodies · at diagnosis · more often in girls
- P < 0.001
HLA risk
- Small sex differences in HLA risk in children <9 years of age
Original publication
Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes. Diabetes Care. Published 12 September 2023. doi:10.
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