Sex differences between mid-life glycaemic traits and brain volume at age 70: a population-based study
Authors' conclusion
Women's later-life brain health may be more vulnerable to midlife hyperglycaemia.
Study context
- Population
- Participants of the 1946 British Birth Cohort with glycaemic measures (age 60–64) and MRI measures (age ∼70)51% men
- Participants
- 453 participants
- Exposure
- Mid-life glycaemic traits and brain volume at age ≈70, by sex
- Outcome
- Association of fasting glucose and insulin resistance at age ∼60 with WBV at age ∼70
- Follow-up
- Age ∼70
Main finding
As reported in the abstract
age ∼70
Women, fasting glucose: β*
−0.07 (−0.13, −0.01), P = .02 (95% CI)
Observational data: associations, not effects.
Further findings
- HOMA-%B not associated with brain outcomes in either sex
Original publication
Sex differences between mid-life glycaemic traits and brain volume at age 70: a population-based study. Eur J Endocrinol. Published 29 April 2025. doi:10.
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