Serum Calcium Concentrations and Risk of All-Cause and Cause-Specific Mortality: Results From 2 Prospective Cohorts
Authors' conclusion
Our findings provide novel insights into the association between serum calcium concentrations and mortality in the general healthy population.
Study context
- Population
- General healthy population, UK Biobank and US National Health and Nutrition Examination Survey (NHANES)UK Biobank and NHANES · UK Biobank 361,662 · US NHANES 36,985
- Exposure
- Albumin-adjusted serum calcium quintiles vs Q3
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Median 12.0 years (UK Biobank)
Methodological detailsUK Biobank and US NHANES cohorts, Cox proportional hazard and restricted cubic spline models
- UK Biobank and US NHANES cohorts
- Cox proportional hazard and restricted cubic spline models
Main finding
As reported in the abstract
All-cause mortality (UK Biobank) · median follow-up 12.0 years
Hazard ratio
1.02
Q1
Hazard ratio
1.10
Q5
- UK Biobank deaths
- 18 327
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| CVD mortality (UK Biobank) · median follow-up 12.0 yearsQ1 vs Q3 | 1.11 |
| CVD mortality (UK Biobank) · median follow-up 12.0 yearsQ5 vs Q3 | 1.25 |
| Cancer mortality (UK Biobank) · median follow-up 12.0 yearsQ5 vs Q1 | 1.09 |
- Cardiovascular disease (CVD) mortality (UK Biobank) — CVD deaths
- 3119 (17.0%)
- Cancer mortality (UK Biobank) — Cancer deaths
- 9599 (52.4%)
Cancer mortality (UK Biobank) · median follow-up 12.0 years
- Linear positive relationship with cancer mortality
All-cause, CVD and cancer mortality (US NHANES)
- Similar results observed in US NHANES
Original publication
Serum Calcium Concentrations and Risk of All-Cause and Cause-Specific Mortality: Results From 2 Prospective Cohorts. J Clin Endocrinol Metab. Published 18 February 2023. doi:10.
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