Serum Annexin A2 concentrations are increased in patients with diabetic cardiomyopathy and are linked to cardiac dysfunctions
Authors' conclusion
Circulating Annexin A2 concentrations might be induced in DbCM patients and were negatively associated with cardiac systolic and diastolic functions, which suggested it might be a predictor of early diagnosis in DbCM and might be a potential therapeutic target for DbCM.
Study context
- Population
- Non-diabetic subjects and T2D patients with or without diabetic cardiomyopathy
- Participants
- 266 subjects
- Exposure
- Serum Annexin A2 in diabetic cardiomyopathy (DbCM) vs T2D without DbCM vs non-diabetic subjects
- Outcome
- Serum Annexin A2 concentrations
Main finding
As reported in the abstract
Serum Annexin A2 concentration
- Serum Annexin A2 higher in DbCM and T2DM vs NGR, especially in DbCM
- DbCM vs NGR: P < 0.05
- T2DM vs NGR: P < 0.05
Observational data: associations, not effects.
Further findings
Correlations of serum Annexin A2
- Negatively associated with left ventricular (LV) ejection fraction (EF), LV fractional shortening (FS), E/A ratio and estimated glomerular filtration rate (eGFR); positively correlated with age, blood urea nitrogen (BUN) and creatinine (Cr) (all P < 0.05)
Annexin A2 tertiles and DbCM (multiple logistic regression)
- Second and third tertiles of Annexin A2 significantly associated with DbCM
- E/A ratio is the independent factor for Annexin A2 when adjusted for LV FS%, BUN and Cr
Original publication
Serum Annexin A2 concentrations are increased in patients with diabetic cardiomyopathy and are linked to cardiac dysfunctions. Diabetes Res Clin Pract. Published 1 December 2022. doi:10.
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