Semaglutide in Adults with Type 1 Diabetes and Obesity
Primary result · Primary composite outcomeResult — go to the resultBetween-group difference 36 percentage points 95% CI 20.6–52.2Authors' conclusion
In adults with type 1 diabetes and obesity, semaglutide treatment, compared with AID use alone, significantly improved achievement of a composite of time in range of greater than 70%, with time below range of less than 4%, and a 5% body weight reduction.
Study context
- Population
- Adults with T1D using an automated insulin delivery (AID) system and BMI ≥30randomized 1:1
- Participants
- 72 adults
- Comparison
- Once-weekly semaglutide vs placebo
- Primary endpoint
- Composite:
- Continuous glucose monitoring (CGM) time 70–180 mg/dl >70%
- Time <70 mg/dl <4%
- Weight reduction ≥5%
- Follow-up
- 26 weeks
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
Primary composite outcome
Between-group difference
36 percentage points
95% CI 20.6–52.2
P < 0.001
By group
Semaglutidevs Placebo
between-group difference 36 percentage points (95% CI 20.6–52.2); P < 0.001
As reported in the abstract
Further findings
| Outcome | Difference in least-squares mean change (percentage points) (95% CI) | |
|---|---|---|
| HbA1c, least-squares mean change from baseline · week 26 | −0.3 (−0.6 to −0.05) | |
| CGM time 70–180 mg/dl, least-squares mean change from baseline · week 26 | 8.8 (3.9–13.7) | |
| −1001020Difference, percentage points (linear scale) |
| Outcome | Difference in least-squares mean change (kg) (95% CI) | |
|---|---|---|
| Body weight, least-squares mean change from baseline · week 26 | −8.8 (−10.6 to −7.0) | |
| −15−10−505Difference, kg (linear scale) |
Safety
Events
| Outcome | Semaglutide | Placebo |
|---|---|---|
| Severe hypoglycemia events | 2 | 2 |
DKA
- No DKA reported
Original publication
Semaglutide in Adults with Type 1 Diabetes and Obesity. NEJM Evid. Published 23 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →