Sellar and perisellar meningiomas: effects on pituitary function in a Spanish cohort observational study
Authors' conclusion
S/PS meningiomas affect the pituitary function in 25% of the cases. However, after the implementation of treatments, hypopituitarism prevails in more than 50% of the cases. They are relatively large tumors and GTR is achieved in one third of the cases in whom hypopituitarism is more prevalent.
Study context
- Population
- Adult Spanish patients with sellar and/or perisellar (S/PS) meningiomas attended in 20 tertiary centers; 74.5% female, median age 61.4 years
- Participants
- 165 patients
- Outcome
- Effects of S/PS meningiomas and their treatments on pituitary function
Methodological detailsmulticenter, 20 tertiary Spanish centers
- Multicenter
- 20 tertiary Spanish centers
Main finding
As reported in the abstract
Hypopituitarism
Hypopituitarism at presentation
34
26.2%
Hypopituitarism after treatments, at last evaluation
86
53.4%
Observational data: associations, not effects.
Further findings
Presentation and tumor characteristics
- Visual disturbance
- 115 (69.7%)
- Headache
- 62 (37.6%)
- Cranial nerve palsy
- 46 (27.9%)
- Median tumor diameter
- 29.1 [22-35.5] mm
- Cavernous sinus infiltration
- 95 (59%)
Initial treatment and surgical outcome
- Surgery
- 128 (77.6%)
- Radiotherapy
- 25 (15.2%)
- Clinical and radiological monitoring
- 12 (7.3%)
- Gross total resection among operated
- 44 (34.4%)
- Incomplete removal among operated
- 84 (65.6%)
- Median follow-up 5.7 [2.9-9.2] years
Original publication
Sellar and perisellar meningiomas: effects on pituitary function in a Spanish cohort observational study. Pituitary. Published 28 December 2024. doi:10.
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