Selective Androgen Receptor Modulators (SARMs) Effects on Physical Performance: A Systematic Review of Randomized Control Trials
Authors' conclusion
SARMs have a positive effect on physical performance and body composition and are associated with moderate rates of mild to moderate adverse effects (AEs) and a low rate of severe AEs.
Study context
- Population
- Studies reporting physical parameter outcomes after SARM intervention; mean age 57.1 years (35.3–75.9)
- Participants
- 970 participants9 studies
- Comparison
- SARMs, pre- vs post-intervention
- Outcome
- Physical performance and body composition, mean values (range)
- Follow-up
- Mean 80 days (14-180)
Methodological detailsPRISMA, three databases
- PRISMA
- Three databases
Pooled result
As reported in the abstract
mean follow-up 80 days (14-180)
- Stair climbing power (5 studies), pre vs post
- 352.24 W (69.79-678.7) vs 315.16 W (89.46-525.73 W)
- One repetition maximum leg press (4 studies), pre vs post
- 1822.77 N (1176.8-2407.3) vs 2191.27 N (1375.87-2462.9 N)
- Short physical performance battery (SPPB) score (2 studies), pre vs post
- 9.15 (7.95-9.9) vs 9.79 (8.88-10.4)
- Lean body mass (7 studies), pre vs post
- 49.46 kg (30.94-63.9) vs 50.86 kg (31.02-67.29)
- Fat mass (5 studies), pre vs post
- 21.99 kg (13.3-33) vs 21.85 kg (12.54-32.16)
Original publication
Selective Androgen Receptor Modulators (SARMs) Effects on Physical Performance: A Systematic Review of Randomized Control Trials. Clin Endocrinol (Oxf). Published 16 September 2024. doi:10.
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