Salt Sensitivity of Blood Pressure in Black Individuals With Striatin and Lysine-specific Demethylase-1 Risk Alleles
Authors' conclusion
Black, but not White, individuals with risk alleles from both LSD1 and STRN (44% of subjects) exhibited a higher degree of SSBP. In light of the MR-related drivers of SSBP in this population, MR blockade may be particularly effective.
Study context
- Population
- Black and White individuals from the HyperPATH cohort with genotype data for LSD1 (rs587,168) and striatin (STRN) diplotype (rs888,083 and rs6,744,560)
- Participants
- 127 Black individuals
- Exposure
- Risk alleles from both LSD1 and STRN vs not
- Outcome
- Salt-sensitive blood pressure (SSBP)
Methodological detailscontrolled low- and liberal-sodium diets, multivariable analysis, replication cohort
- Controlled low- and liberal-sodium diets
- Multivariable analysis
- Replication cohort
Main finding
As reported in the abstract
SSBP, Black individuals
P < 0.0001
Observational data: associations, not effects.
Further findings
SSBP, hypertensive Black individuals
P < 0.0001
- Salt-sensitive blood pressure (SSBP), second cohort of 37 Black individuals
- P = 0.029
SSBP, second cohort of 37 Black individuals
- Results confirmed in a second cohort of 37 Black individuals
SSBP, White individuals
- In 396 White individuals, no differences were observed
Original publication
Salt Sensitivity of Blood Pressure in Black Individuals With Striatin and Lysine-specific Demethylase-1 Risk Alleles. J Clin Endocrinol Metab. Published 27 February 2025. doi:10.
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