Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study
Main finding · PRFV index cut-off values and eGFR<60 (multivariate-adjusted)Result — go to the resultOdds ratio 6.01 95% CI 2.20–16.4Authors' conclusion
PRFV is associated with low eGFR in patients with T2DM but not in those without T2DM. This suggests that PRF accumulation is more closely related to the onset and progression of diabetic kidney disease (DKD) than non-DKD. Clarifying the mechanisms through which PRF influences DKD development could pave the way for novel prevention and treatment strategies.
Study context
- Population
- Japanese individuals with or without T2DM; perirenal fat volume (PRF volume (PRFV)) from non-contrast CT, indexed to body surface area
- Participants
- 473 individuals
- Exposure
- Individuals with T2DM vs without T2DM
- Diabetes mellitus (DM)n = 271
- non-DMn = 202reference
- Outcome
- Association of PRFV index cut-off values with eGFR <60 mL/min/1.73 m², proteinuria onset, or both (multivariate-adjusted ORs)
Main finding
As reported in the abstract
PRFV index cut-off values and eGFR<60 (multivariate-adjusted)
Odds ratio
6.01
95% CI 2.20–16.4
P < 0.001
DMvs non-DM
OR 6.01 (95% CI 2.20–16.4); P < 0.001
Observational data: associations, not effects.
Further findings
Body composition and kidney measures, DM vs non-DM
- Body mass index (BMI), visceral fat area and waist circumference comparable between groups
- Kidney volume, PRFV and PRFV index higher with T2DM than without
Original publication
Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study. BMJ Open Diabetes Res Care. Published 11 March 2024. doi:10.
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