Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes
Authors' conclusion
SIRD features higher IHLs and nominally higher VAT volume, which likely contribute to increased cardiovascular risk, highlighting implications for tailored prevention and treatment.
Study context
- Population
- Participants of the German Diabetes Study assigned to diabetes clusters using a validated algorithm
- Participants
- 420 participants
- Exposure
- Severe insulin-resistant diabetes (SIRD) vs other diabetes endotypes
- Outcome
- Skeletal muscle (IMCL) or adipose tissue lipids (VAT and subcutaneous adipose tissue (SAT) volumes) elevated in SIRD
Methodological detailsGerman Diabetes Study (GDS) cohort, 1H-magnetic resonance methods
- German Diabetes Study (GDS) cohort
- 1H-magnetic resonance methods
Main finding
As reported in the abstract
IHLs, VAT, SAT and IMCLs in SIRD vs other endotypes
- All endotypes featured comparable intramyocellular lipids (IMCLs)
- SIRD vs Other endotypes: P < 0.01
- SIRD vs Other endotypes: all P < 0.05
Observational data: associations, not effects.
Further findings
Correlation with cardiovascular risk scores (Framingham)
- Visceral adipose tissue (VAT) volume, Framingham r
- 0.661
- Intrahepatic lipids (IHLs), Framingham r
- 0.548
- P
- P < 0.05
Polygenic risk scores for VAT
- Polygenic risk scores for VAT were associated with higher cardiovascular risk
Original publication
Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes. Diabetes Care. Published 17 June 2025. doi:10.
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