Risk of impulse control disorders in patients with Cushing’s disease: do not blame cabergoline but do not give up caution
Authors' conclusion
CBG-treated patients with CD appeared to have a low risk of ICDs, suggesting that CBG still holds promise as a safe agent in CD.
Study context
- Population
- Patients with Cushing's disease (CD) at five referral centers in Istanbul; prospective arm: patients scheduled for cabergoline (CBG)prospective cohort n = 14
- Participants
- 34 vs 34
- Exposure
- Cabergoline-treated vs CBG-naïve patients with CD
- CBG-treatedn = 34
- CBG-naïven = 34reference
- Outcome
- Risk of new-onset ICDs after CBG initiation and frequency of ICDs in CBG-treated patients with CD
Methodological detailsnaturalistic, multicentre (five referral centers), matched CBG-naïve controls in cross-sectional arm
- Naturalistic
- Multicentre (five referral centers)
- Matched CBG-naïve controls in cross-sectional arm
Main finding
As reported in the abstract
Frequency of ICDs (cross-sectional arm)
P = 1.0
Observational data: associations, not effects.
Further findings
Prospective cohort: new-onset impulse control disorders (ICDs) and impulsivity after CBG · follow-up 7.3 ± 2.3 months
- Developed compulsive gambling after CBG
- 1 patient
- No significant changes in impulsivity scores during follow-up
Safety
Psychiatric events after CBG (prospective cohort)
Patient
- Developed major depressive episode
- 1
- Developed compulsive gambling
- 1
Original publication
Risk of impulse control disorders in patients with Cushing’s disease: do not blame cabergoline but do not give up caution. Pituitary. Published 20 July 2023. doi:10.
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