Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study
Authors' conclusion
Patients with adenomas demonstrate a higher incidence of psychiatric and sleep disorders, possibly due to the underlying subtle increase in cortisol secretion.
Study context
- Population
- Patients with adrenal adenoma without overt hormone excess, Olmsted County, MN, 1995–2017; 58% women, median age at diagnosis 63 yearsmatched cohort
- Exposure
- Adrenal adenoma vs referents without adrenal adenoma
- Adenoman = 1,004
- Outcome
- Baseline and incident diagnoses of dementia, psychiatric or sleep disorders (ICD codes)
- Follow-up
- Median 6.8 years
Methodological detailsage- and sex-matched 1:1
- Age- and sex-matched 1:1
Main finding
As reported in the abstract
Incident psychiatric and sleep disorders and dementia
Estimate (95% CI)
Between Adenoma and Referents
aHR depression 1.7(1.3–2.2)
Adenomavs Referents
aHR anxiety 1.4(1.1–1.7)
Between Adenoma and Referents
aHR insomnia 1.4(1.0–1.9)
Between Adenoma and Referents
aHR sleep-related breathing disorders 1.5(1.1–1.9)
Between Adenoma and Referents
aHR hypersomnias 2.1(1.0–4.2)
Between Adenoma and Referents
aHR parasomnias 2.1(1.0–4.2)
Between Adenoma and Referents
aHR sleep-related movement disorders 1.5(1.0–2.1)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Baseline diagnosesAdenomavs ReferentsAdjusted for age, sex, education, BMI and tobacco use | aOR depression 1.3 (95% CI 1.1–1.6) | |
| Baseline diagnosesAdenomavs ReferentsAdjusted for age, sex, education, BMI and tobacco use | aOR anxiety 1.4 (95% CI 1.1–1.8) | |
| Baseline diagnosesAdenomavs ReferentsAdjusted for age, sex, education, BMI and tobacco use | aOR substance abuse 2.4 (95% CI 1.7–3.4) | |
| 0.20.5125Ratio (log scale) |
Original publication
Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study. Eur J Endocrinol. Published 6 October 2023. doi:10.
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