Identifying factors associated with subsequent diagnosis of adrenal adenoma: a population-based historical case–control study
Authors' conclusion
Compared to controls with prior imaging, patients with adrenal adenoma had higher prevalence of obesity, low socioeconomic status, tobacco use, and diabetes 5-10 years prior to index date. In particular, increased BMI and tobacco use were independent risk factors associated with increased odds of adrenal adenoma diagnosis.
Study context
- Population
- Adults with adrenal adenoma without overt hormone excess, 2005–2017; median age 63 years, 56% women670 cases
- Exposure
- Adrenal adenoma cases vs controls with prior imaging
- Casesn = 670
- Outcome
- Frequency of social/metabolic risk factors and ORs for adrenal adenoma diagnosis
- Follow-up
- 5-10 years prior to index date
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Increased body mass index (BMI), multivariable OR for adrenal adenoma diagnosis
OR 1.18
95% CI 1.07–1.32
Tobacco use, multivariable OR for adrenal adenoma diagnosis
OR 1.41
95% CI 1.06–1.87
Observational data: associations, not effects.
Original publication
Identifying factors associated with subsequent diagnosis of adrenal adenoma: a population-based historical case–control study. Eur J Endocrinol. Published 9 September 2025. doi:10.
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