Risk factors for obesity in adulthood among survivors of childhood cancer
Authors' conclusion
Long-term follow-up of CCSs should include weight follow-up during adulthood.
Study context
- Population
- Childhood cancer survivors of the French Childhood Cancer Survivor Study cohort303 with obesity
- Participants
- 3,199 survivors
- Exposure
- Risk factors for obesity in childhood cancer survivors
- Outcome
- Obesity in adulthood
Methodological detailsadjusted for social deprivation index and sex
- Adjusted for social deprivation index and sex
Main finding
As reported in the abstract
Obesity by pituitary radiation dose
Each group vs no pituitary radiotherapyRelative risk (95% CI)
6 to 20 Gy
1.9(1.2–3.1)
20 to 40 Gy
2.5(1.7–3.7)
≥40 Gy
2.6(1.6–4.3)
- Etoposide administration increased risk of obesity (RR)
- 1.7; 95% CI: 1.1-2.6
Observational data: associations, not effects.
Further findings
Prevalence of obesity in CCSs vs expected from general French population
- Obesity in CCSs
- 9.5%; 95% CI: 8.5%-10.5%
- Expected from general French population rates
- 12.5%; p = 0.0001
- Brain tumor survivors significantly more likely to develop obesity than general French population
- P = 0.0001
Original publication
Risk factors for obesity in adulthood among survivors of childhood cancer. Obesity (Silver Spring). Published 15 June 2023. doi:10.
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