Placental epigenetic marks related to gestational weight gain reveal potential genes associated with offspring obesity parameters
Authors' conclusion
These results suggest that placental regulation of FRAT1, SNX5, and KCNK3 relates to obesity parameters in offspring exposed to excessive GWG and thereby could condition the risk for future metabolic disorders.
Study context
- Population
- Placentas from mothers with different degrees of gestational weight gain (GWG); offspring assessed at 6 years of age24 screening + 90 validation placentas
- Outcome
- Placental DNA methylation marks associated with GWG and their association with offspring obesity parameters
- Follow-up
- School age (6 years)
Methodological detailsscreening and validation samples, global methylation array
- Screening and validation samples
- Global methylation array
Main finding
As reported in the abstract
6 years of age
CpG sites associated with GWG in screening analysis
104 CpG sites
97 genes
Original publication
Placental epigenetic marks related to gestational weight gain reveal potential genes associated with offspring obesity parameters. Obesity (Silver Spring). Published 14 June 2023. doi:10.
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