Risk factor control and incident cardiovascular disease in patients with diabetes: Sex‐specific relations
Authors' conclusion
Our findings highlighted the importance of raising awareness of sex differences in the management of CVD risk factors among patients with diabetes.
Study context
- Population
- UK Biobank participants with diabetes and matched non-diabetes controls; risk factors: HbA1c <53 mol/mol (7%), BP <140/90 mm/Hg, LDL-C <100 mg/dl, non-current smoking, absence of microalbuminuriamatched cohort
- Participants
- 17,260 vs 86,300
- Exposure
- Number of risk factors within target range in patients with diabetes vs non-diabetes controls, by sex
- Diabetesn = 17,260
- Non-diabetes controlsn = 86,300reference
- Outcome
- Incident CVD
- Follow-up
- Median 13.3 years
Methodological detailsUK Biobank, matched on age, sex and assessment centre
- UK Biobank
- Matched on age, sex and assessment centre
Main finding
As reported in the abstract
Incident CVD by number of risk factors within target range
- Incident cardiovascular diseases (CVD) cases (incl. 2807 ischaemic heart disease and 793 strokes)
- 3338
Observational data: associations, not effects.
Further findings
Relative importance of risk factors by sex
- Clinical biomarkers (e.g. HbA1c, BP) showed greater relative importance than other factors in women; socio-economic and psychological factors (e.g. education, depression) similar relative importance to clinical biomarkers in men with diabetes
Original publication
Risk factor control and incident cardiovascular disease in patients with diabetes: Sex‐specific relations. Diabetes Obes Metab. Published 16 January 2024. doi:10.
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