Association of type 2 diabetes according to the number of cardiovascular risk factors within the recommended range with neuropathy – The Maastricht Study
Authors' conclusion
Achieving ≥6 risk factors on target was associated with neuropathy prevalence similar to individuals without diabetes, suggesting comprehensive risk factor control may help prevent neuropathy.
Study context
- Population
- Participants of The Maastricht Study with and without T2D; risk factors: HbA1c, blood pressure, BMI, lipids, albuminuria, smoking, physical activity, diet845 with T2D
- Participants
- 3,764 participants
- Exposure
- T2D by number of 8 cardiovascular risk factors on target vs normal glucose metabolism
- Normal glucose metabolismn = 2,919reference
- Outcome
- Neuropathy (autonomic, sensory, peripheral nerve function, neuropathic pain)
Methodological detailspopulation-based cohort (The Maastricht Study)
- Population-based cohort (The Maastricht Study)
Main finding
As reported in the abstract
Neuropathy
Each group vs normal glucose metabolismAdjusted odds ratio (95% CI)
0-2
14.86(7.67–28.82)
3-5
3.18(2.01–5.04)
6-8
1.07(0.25–4.56)
Observational data: associations, not effects.
Further findings
Neuropathy prevalence
- T2D
- 7.8%
- Without diabetes
- 1.3%
Original publication
Association of type 2 diabetes according to the number of cardiovascular risk factors within the recommended range with neuropathy – The Maastricht Study. Diabetes Res Clin Pract. Published 14 March 2026. doi:10.
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