Risk Assessment of Diabetes Mellitus During and After Pregnancy in Women With Prolactinomas
Authors' conclusion
Low PRL levels before pregnancy may be detrimental to FG during pregnancy. CAB duration and dose may influence long-term glucose tolerance, besides family history and BMI. Preconception metabolic management should be recommended to reduce the risk of gestational and type 2 diabetes mellitus.
Study context
- Population
- Women with prolactinomas treated with cabergoline (CAB), evaluated before conception, during pregnancy and up to 10 years after delivery; CAB discontinued in pregnancy, restarted in 57.7% after delivery due to recurrent hyperprolactinemia (RH)
- Participants
- 52 women
- Outcome
- PRL and glucose metabolism during and after pregnancy
Main finding
As reported in the abstract
- Inverse correlation between prolactin (PRL) and FG, first trimester
- P = .032
- Inverse correlation between PRL and FG, third trimester
- P = .048
- Serum PRL before conception predictive of third-trimester FG
- t = 2.603; P = .048
- Positive correlation between BMI and FG at 10 years after delivery, particularly in overweight/obese patients requiring higher CAB doses
- P = .03
Observational data: associations, not effects.
Original publication
Risk Assessment of Diabetes Mellitus During and After Pregnancy in Women With Prolactinomas. J Clin Endocrinol Metab. Published 2 May 2024. doi:10.
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