Lipids & metabolic liver disease
Revisiting an old relationship: the causal associations of the ApoB/ApoA1 ratio with cardiometabolic diseases and relative risk factors—a mendelian randomization analysis
Authors' conclusion
This MR study provides evidence supporting the significant causal relationship between the ApoB/ApoA1 ratio and CMD and its risk factors. Moreover, it demonstrates the mediating effect of the ApoB/ApoA1 ratio in CMD and its risk factors. These findings suggest that the ApoB/ApoA1 ratio may serve as a potential indicator for identifying the risk of developing CMD in participants.
Study context
- Population
- European GWAS data on the ApoB/ApoA1 ratio, cardiometabolic diseases (CMD) and their risk factors
- Outcome
- Causal association of ApoB/ApoA1 ratio with CMD
Methodological detailsunivariable and multivariable Mendelian Randomization (MR), bidirectional MR, mediation analysis
- Univariable and multivariable MR
- Bidirectional MR
- Mediation analysis
Main finding
As reported in the abstract
Higher ApoB/ApoA1 ratio associated with various CMD, incl. ischemic heart disease, MACE, aortic aneurysm, cerebral ischemic disease
all PFDR<0.05
Further findings
Causal association of ApoB/ApoA1 ratio with CMD risk factors
- ApoB/ApoA1 ratio significantly associated with CMD risk factors, e.g. HbA1c, fasting insulin, WHR, sedentary behavior
- all PFDR<0.05
Mediation
- ApoB/ApoA1 ratio played a mediating role in CMD and related risk factors
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →