Retrospective analyses of clinical features in 28 Chinese patients with type V osteogenesis imperfecta: new perspectives in an old issue
Authors' conclusion
This retrospective study summarized the clinical features and highlighted the abnormalities in elbow, hip joint, and growth plate in type V OI patients. Our study contributed to a more comprehensive clinical spectrum of type V OI. We also characterized the natural progression of HPC formation and resorption in patients in different ages. The use of bisphosphonate treatment is effective in improving bone mineral density in type V OI patients, and whether indomethacin can reduce incidence of HPC formation deserves further investigation.
Study context
- Population
- Patients with type V osteogenesis imperfecta (clinically diagnosed or genetically confirmed IFITM5 c.-14C > T mutation), inpatients at The Hong Kong University-Shenzhen Hospital
- Participants
- 28 patients
- Outcome
- Prevalence of type V radiological features
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Radial head dislocation (RHD)
100%
Calcification of interosseous membrane (CIM)
100%
Hyperplastic callus (HPC)
44%
Scoliosis
50%
Observational data: associations, not effects.
Further findings
BMD with bisphosphonate treatment
- Significant increase in BMD in patients with bisphosphonate treatment
Postoperative HPC after preoperative indomethacin
- Developed HPC postoperatively
- Twenty-five percent (3/12)
- HPCs absorbed 2 years later in young patients
- 2
Original publication
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