Reproductive Lifespan and Reproductive Factors in Relation to Dementia Risk in Postmenopausal Women With Type 2 Diabetes
Main finding · All-cause dementiaResult — go to the resultHazard ratio 0.73 95% CI 0.69–0.78Authors' conclusion
A longer reproductive lifespan was linked to a reduced risk of dementia in postmenopausal women with type 2 diabetes.
Study context
- Population
- Postmenopausal women with T2D aged over 40 years who underwent health examinations in 2009; mean age 64.5 ± 8.0 years, mean reproductive lifespan 33.6 ± 4.5 years
- Participants
- 159,751 women
- Exposure
- Reproductive lifespan ≥40 years vs <30 years
- Outcome
- Incident all-cause dementia (diagnosis codes and antidementia medication prescriptions)
- Follow-up
- Median 8.3 years
Methodological detailsNational Health Information Database, Cox proportional hazards regression
- National Health Information Database
- Cox proportional hazards regression
Main finding
All-cause dementia
Hazard ratio
0.73
95% CI 0.69–0.78
≥40 yearsvs <30 years
HR 0.73 (95% CI 0.69–0.78)
As reported in the abstract
- All-cause dementia cases
- 24,218
Observational data: associations, not effects.
Further findings
| Outcome | Lower risk |
|---|---|
| All-cause dementia by parityParity 1 vs Parity 0 | 27% |
| All-cause dementia by HRT useHRT >5 years vs No HRT | 17% |
Alzheimer disease and vascular dementia · median follow-up 8.3 years
- Alzheimer disease cases
- 18,819
- Vascular dementia cases
- 2,743
- Comparable effects for both Alzheimer disease and vascular dementia
Original publication
Reproductive Lifespan and Reproductive Factors in Relation to Dementia Risk in Postmenopausal Women With Type 2 Diabetes. Diabetes Care. Published 5 December 2025. doi:10.
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