Relationships among Helicobacter pylori seropositivity, the triglyceride-glucose index, and cardiovascular disease: a cohort study using the National Health and Nutrition Examination Survey (NHANES) database
Authors' conclusion
H. pylori seropositivity may indirectly elevate the risk of CVD and mortality via the TGI. Combining the patient's H. pylori serological status with their TGI could enhance the predictive ability for CVD occurrence and related mortality. Therefore, the clinical practice of screening for and eradicating H. pylori in CVD patients may be anticipated.
Study context
- Population
- NHANES participants; 4,488 (47.75%) H. pylori-IgG-positive, 3,934 (41.86%) with cardiovascular diseases (CVD)
- Participants
- 9,399 participants
- Exposure
- H. pylori seropositivity and triglyceride-glucose index (TGI) vs lower TGI/seronegativity
- Outcome
- Risk of CVD (logistic regression) and all-cause mortality (Cox model)
Methodological detailsNHANES III (1988-1994) and NHANES (1999-2000), logistic regression, Cox proportional hazards model, restricted cubic spline, mediation analyses
- NHANES III (1988-1994) and NHANES (1999-2000)
- Logistic regression
- Cox proportional hazards model
- Restricted cubic spline
- Mediation analyses
Main finding
As reported in the abstract
CVD risk, general population
TGI ≥75th percentile & H. pylori-IgG-positive: highest CVD risk, OR
1.487
95% CI 1.088–2.033
Observational data: associations, not effects.
Further findings
All-cause mortality among patients with CVD
- TGI ≥75th percentile & H. pylori-IgG-positive: higher all-cause mortality (ACM) risk, HR
- 1.227 (95% CI 1.009-1.491)
Mediation via TGI
- Significant mediating effect of H. pylori via TGI on CVD occurrence
- Pindir = 0.004
- Significant mediating effect of H. pylori via TGI on mortality
- Pindir = 0.004
Original publication
Relationships among Helicobacter pylori seropositivity, the triglyceride-glucose index, and cardiovascular disease: a cohort study using the NHANES database. Cardiovasc Diabetol. Published 18 December 2024. doi:10.
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