Type 1 diabetes

The Relationship Between the Percent Coefficient of Variation of Sensor Glucose Levels and the Risk of Severe Hypoglycemia or Non-Severe Hypoglycemia in Patients With Type 1 Diabetes: Post Hoc Analysis of the ISCHIA Study

J Diabetes Sci TechnolPublished Post hoc analysis of the ISCHIA crossover randomised controlled trial

Study context

Population
Patients with T1D using MDI; blinded continuous glucose monitoring (CGM) data during the Control period (84 days)
Participants
93 patients
Primary endpoint
%CV discrimination thresholds (ROC) corresponding to LBGI > 5, LBGI ≥ 2.5 and occurrence of SH
Follow-up
Control period (84 days)
Methodological detailsblinded CGM data from Control period
  • Blinded CGM data from Control period

Primary result

As reported in the abstract

%CV thresholds by ROC analysis

%CV corresponding to low blood glucose index (LBGI) > 5

42.2%

%CV corresponding to LBGI ≥ 2.5

37.0%

Patients with severe hypoglycemia (SH) episodes

3

%CV corresponding to occurrence of SH

40.7%

Original publication

The Relationship Between the Percent Coefficient of Variation of Sensor Glucose Levels and the Risk of Severe Hypoglycemia or Non-Severe Hypoglycemia in Patients With Type 1 Diabetes: Post Hoc Analysis of the ISCHIA Study. J Diabetes Sci Technol. Published 17 February 2025. doi:10.1177/19322968251318756

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