Relationship between life’s essential 8, vitamin D, and cardiometabolic outcomes

Diabetes Res Clin PractPublished Cross-sectional study

Authors' conclusion

These findings underscore that higher CVH scores, assessed by Life's Essential 8, are associated with lower risks of cardiometabolic outcomes. Improving CVH contributes to reducing the burden of disease and promoting human health.

Study context

Population
Adult participants of the National Health and Nutrition Examination Survey (2007–2018)
Participants
21,913 participants
Exposure
Low vs moderate vs high cardiovascular health (CVH)
  • Low CVHn = 6,193
  • Moderate CVHn = 14,080
  • High CVHn = 1,640
Outcome
Association between CVH and cardiometabolic outcomes

Main finding

As reported in the abstract

Cardiometabolic outcomes

Observational data: associations, not effects.

Further findings

Predictive ability of CVH metrics (ROC)

Blood glucose and blood pressure had higher predictive values for CVD, CKD, hypertension and diabetes

Interaction with vitamin D

Significant interaction between CVH and vitamin D

Original publication

Relationship between life’s essential 8, vitamin D, and cardiometabolic outcomes. Diabetes Res Clin Pract. Published 22 February 2025. doi:10.1016/j.diabres.2025.112057

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