Relationship Between Insulin Sensitivity and Hyperinsulinemia in Early Insulin Resistance is Sex-dependent
Authors' conclusion
In the natural development of IR in men, it appears that hyperinsulinemia is a compensatory adaptation to peripheral IR rather than its cause.
Study context
- Population
- Healthy young lean normoglycemic, glucose-tolerant men and women
- Exposure
- Women vs Men
- Outcome
- Relationship between hyperinsulinemia and insulin sensitivity
Methodological detailsVastus lateralis muscle biopsies, followed by IV glucose tolerance test; insulin secretion and whole-body insulin sensitivity calculated
- Vastus lateralis muscle biopsies, followed by IV glucose tolerance test; insulin secretion and whole-body insulin sensitivity calculated
Main finding
As reported in the abstract
Association of insulin sensitivity with fasting insulin and glucose-stimulated insulin secretion
- Insulin sensitivity significantly and negatively associated with fasting plasma insulin and insulin secretion in response to glucose infusion
- All correlations became stronger in women
- All correlations became insignificant in men
Observational data: associations, not effects.
Further findings
Association of insulin sensitivity with type I skeletal muscle fiber expression and resting heart rate
- Insulin sensitivity significantly correlated with type I fiber expression and resting heart rate to similar extents in both sexes
Original publication
Relationship Between Insulin Sensitivity and Hyperinsulinemia in Early Insulin Resistance is Sex-dependent. J Clin Endocrinol Metab. Published 13 May 2025. doi:10.
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