Relationship Between Daytime Versus Nighttime Continuous Glucose Monitoring Metrics with A1C in Adults with Type 1 Diabetes
Authors' conclusion
Daytime versus nighttime glycemic control has similar influence on A1C in adults with T1D.
Study context
- Population
- Adults with T1D (age 39 ± 15 years, diabetes duration 20 ± 12 years, A1C 7.3% ± 1.4%, 53% female)
- Participants
- 407 adults2 studies
- Comparison
- Daytime vs nighttime CGM metrics, within 5 A1C categories
- Primary endpoint
- Association of daytime vs nighttime CGM metrics (mean glucose, TIR 70-180 mg/dL, TTIR 70-140 mg/dL, TAR >180 mg/dL) with A1C, within five A1C categories
Primary result
As reported in the abstract
Mean glucose, daytime vs nighttime, by A1C category
- A1C <7%: daytime vs nighttime mean glucose
- 143.2 ± 22.7 vs. 143.6 ± 25.0
- A1C 7.0%-7.9%: daytime vs nighttime mean glucose
- 171.4 ± 17.3 vs. 175.3 ± 28.8
- A1C 8.0%-8.9%: daytime vs nighttime mean glucose
- 193.4 ± 19.4 vs. 195.3 ± 29.5
- A1C 9.0%-9.9%: daytime vs nighttime mean glucose
- 214.9 ± 28.8 vs. 219.7 ± 36.1
- A1C ≥10%: daytime vs nighttime mean glucose
- 244.0 ± 39.0 vs. 239.9 ± 50.9
Further findings
Other CGM metrics (time in range (TIR), TTIR, TAR), daytime vs nighttime
- No difference between CGM metrics by daytime vs nighttime within five A1C groups
Differences between A1C groups in daytime vs nighttime mean glucose, TIR, TTIR, TAR
- Not statistically significant
- all P > 0.05
Original publication
Relationship Between Daytime Versus Nighttime Continuous Glucose Monitoring Metrics with A1C in Adults with Type 1 Diabetes. Diabetes Technol Ther. Published 11 November 2022. doi:10.
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