A Comparison of Continuous Glucose Monitoring Estimated Hemoglobin A1c in Adults with Type 1 or Type 2 Diabetes
Authors' conclusion
HbA1c on average was higher in T2D than T1D for a given mean glucose, but after accounting for race, there was no meaningful difference in the mean glucose-HbA1c relationship comparing T1D and T2D. The mean glucose-HbA1c relationship differs in African American compared with White individuals, but does not appear to differ comparing White non-Hispanic to Hispanic individuals.
Study context
- Population
- Adults with T1D or T2D from four clinical trials; mean age 57 ± 15 years (T1D) and 58 ± 10 years (T2D)
- Participants
- 343 adults4 clinical trials
- Comparison
- T1D vs T2D: Continuous glucose monitoring (CGM) mean glucose–hemoglobin A1c (HbA1c) relationship
- T1Dn = 191reference
- T2Dn = 152
- Outcome
- Relationship of CGM-measured mean glucose with laboratory-measured HbA1c
Methodological detailsleast squares linear regression
- Least squares linear regression
Pooled result
As reported in the abstract
CGM mean glucose–HbA1c relationship
- Difference largely attributable to the difference in proportion of African Americans between T1D and T2D
- T2D vs T1D: P = 0.002
Further pooled results
Mean glucose–HbA1c relationship stratified by race
- Only a small difference between T1D non-African Americans and T2D non-African Americans
- Relationship appeared similar for White non-Hispanic and Hispanic individuals
Original publication
A Comparison of Continuous Glucose Monitoring Estimated Hemoglobin A1c in Adults with Type 1 or Type 2 Diabetes. Diabetes Technol Ther. Published 22 December 2022. doi:10.
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