Continuous Glucose Monitoring Metrics and Hemoglobin A1c Relationship in Patients with Type 2 Diabetes Treated by Hemodialysis
Authors' conclusion
In patients with diabetes and ESKD treated by hemodialysis, the GMI has a strong correlation with TIR, while HbA1c underestimated the average glucose and GMI.
Study context
- Population
- Adults aged 18–80 years with T2D (hemoglobin A1c (HbA1c) 5%-12%) treated by hemodialysis for at least 90 days; mean age 57.7 ± 9.3 years, 58% female, 86% non-Hispanic black
- Participants
- 59 adults
- Outcome
- Correlation between CGM metrics (mean glucose, GMI, TIR 70-180 mg/dL) and HbA1c
- Follow-up
- 10 days of CGM (Dexcom G6 Pro)
Main finding
As reported in the abstract
- Continuous glucose monitoring (CGM) mean glucose, mean ± SD
- 188.9 ± 45 mg/dL (95% CI: 177.2, 200.7)
- Mean HbA1c
- 7.1% ± 1.3%
- Mean glucose management indicator (GMI)
- 7.8% ± 1.1%
- Difference between GMI and HbA1c
- 0.74% ± 0.95
- Correlation GMI vs TIR 70-180 mg/dL (strong negative)
- r = −0.96
- Correlation GMI vs HbA1c (moderate)
- r = 0.68
Observational data: associations, not effects.
Further findings
Discordance between HbA1c and GMI
- Discordance <0.5%
- Up to 29%
- Discordance 0.5%-1%
- 22%
- Discordance >1%
- 49%
Original publication
Continuous Glucose Monitoring Metrics and Hemoglobin A1c Relationship in Patients with Type 2 Diabetes Treated by Hemodialysis. Diabetes Technol Ther. Published 14 June 2024. doi:10.
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