Relationship between the circulating N-terminal pro B-type natriuretic peptide and the risk of carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a CSCD-TCM plus study in China
Authors' conclusion
An increase in NT-proBNP was significantly associated with the risk of CAP in patients with CHD, especially in males and patients aged > 60 years, and exhibited specific characteristics under different glucose metabolism states.
Study context
- Population
- Patients with coronary heart disease (CHD) in normoglycemic, prediabetes and diabetes mellitus (DM) glucose metabolic states, China
- Participants
- 5,093 patients
- Exposure
- NT-proBNP tertiles and risk of carotid plaque
- Outcome
- Carotid plaque (CAP)
Main finding
As reported in the abstract
Relative increase in correlation between NT-proBNP change per SD and carotid plaques (CAP) incidence
37%
Observational data: associations, not effects.
Further findings
CAP by subgroup
- Association also present in males, patients aged >60 years, and pre-DM and DM states
Plaque nature
- Hypoechoic plaques more likely at T1, mixed plaques at T3
Diagnostic accuracy of NT-proBNP for CAP
- AUC
- 0.627 (95% CI 0.592-0.631)
- Sensitivity
- 50.7%
- Specificity
- 68.0%
Original publication
Relationship between the circulating N-terminal pro B-type natriuretic peptide and the risk of carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a CSCD-TCM plus study in China. Cardiovasc Diabetol. Published 2 November 2023. doi:10.
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