The relative and combined ability of stress hyperglycemia ratio and N-terminal pro-B-type natriuretic peptide to predict all-cause mortality in diabetic patients with multivessel coronary artery disease
Main finding · All-cause mortalityResult — go to the resultHazard ratio 12.244 95% CI 5.828–25.721Authors' conclusion
SHR and NT-proBNP independently and jointly predicted all-cause mortality in diabetic patients with MVD, suggesting that strategies to improve risk stratification in these patients should incorporate SHR and NT-porBNP into risk algorithms.
Study context
- Population
- Diabetic patients with multivessel coronary artery disease (CAD) who underwent coronary angiography at Tianjin Chest Hospital, January–December 2016138 died
- Participants
- 1,148 patients
- Exposure
- Stress hyperglycemia ratio (SHR) and NT-proBNP levels for prediction of all-cause mortality
- Outcome
- All-cause mortality
- Follow-up
- Mean 4.2 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
12.244
95% CI 5.828–25.721
P < 0.001
SHR-H and NT-proBNP-Hvs SHR-L and NT-proBNP-L
HR 12.244 (95% CI 5.828–25.721); P < 0.001
Observational data: associations, not effects.
Further findings
Discrimination for all-cause mortality
- AUC, SHR
- 0.615
- AUC, NT-proBNP
- 0.699
- Adding either marker to original models significantly improved C-statistic and integrated discrimination improvement (all P < 0.05)
- Combining SHR and NT-proBNP into the original model provided maximal prognostic information
Original publication
The relative and combined ability of stress hyperglycemia ratio and N-terminal pro-B-type natriuretic peptide to predict all-cause mortality in diabetic patients with multivessel coronary artery disease. Cardiovasc Diabetol. Published 11 March 2024. doi:10.
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