Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators
Authors' conclusion
In persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low-grade inflammation. A considerable part (20%-40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity-induced inflammation in T2D.
Study context
- Population
- Persons with recently diagnosed T2D
- Participants
- >9,000 persons
- Outcome
- Association between abdominal adiposity (waist circumference) and low-grade inflammation (TNF-α, IL-6, hsCRP), and its mediation by physical activity, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension and comorbidities
Methodological detailsmultiple mediation analysis using structural equation modelling, adjusted for age and sex
- Multiple mediation analysis using structural equation modelling
- Adjusted for age and sex
Main finding
As reported in the abstract
Inflammatory markers per 1-SD increase in waist circumference (SD = 15 cm)
SD increase in TNF-α (SD = 1.5 pg/mL)
22%
SD increase in IL-6 (SD = 4.4 pg/mL)
35%
SD increase in high-sensitivity C-reactive protein (hsCRP) (SD = 6.9 mg/L)
46%
Observational data: associations, not effects.
Further findings
Mediators of the adiposity–inflammation association (proportion mediated)
- Hyperinsulinaemia (fasting C-peptide), most important mediator
- 9%-25%
- Low physical activity
- 5%-7%
- High TG levels
- 2%-6%
- Greater comorbidity and higher HbA1c (statistically significant, minor impact)
- 1%-2%
Original publication
Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators. Diabetes Obes Metab. Published 11 March 2024. doi:10.
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