A six-month low-carbohydrate diet high in fat does not adversely affect endothelial function or markers of low-grade inflammation in patients with type 2 diabetes: an open-label randomized controlled trial
Authors' conclusion
A LCD high in fat for six months does not adversely affect endothelial function or selected markers of low-grade inflammation, which suggests that this nutritional approach does not increase the risk of cardiovascular disease.
Study context
- Population
- Patients with T2D64 assessed at 6 months
- Participants
- 71 patients
- Comparison
- Non-calorie-restricted low-carbohydrate diet (LCD) high in fat vs control diet for 6 months
- Primary endpoint
- Endothelial function (brachial FMD and NID by US) and markers of low-grade inflammation (plasma IL-6, serum hsCRP)
- Follow-up
- 6 months
Methodological detailsopen-label, randomized 2:1
- Open-label
- Randomized 2:1
Primary result
As reported in the abstract
- FMD and NID unaltered in both groups after 6 months
- Lack of changes in FMD and NID with LCD persisted after adjustment for cardiovascular risk factors
- LCD vs Control diet: P = 0.34
- LCD vs Control diet: P = 0.53
Further findings
| Outcome | P value |
|---|---|
| Circulating hsCRP and IL-6 · 6 monthsLCD vs Control diet | P = 0.25 |
| Circulating hsCRP and IL-6 · 6 monthsLCD vs Control diet | P = 0.07 |
Circulating high-sensitivity C-reactive protein (hsCRP) and IL-6 · 6 months
- hsCRP and IL-6 decreased only with LCD (both p < 0.05)
Original publication
A six-month low-carbohydrate diet high in fat does not adversely affect endothelial function or markers of low-grade inflammation in patients with type 2 diabetes: an open-label randomized controlled trial. Cardiovasc Diabetol. Published 17 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →