Metabolic Profiles of Type 2 Diabetes and Their Association With Renal Complications
Authors' conclusion
We identified 6 prevalent metabolic profiles in patients with T2D. Severe hyperglycemia and moderate dyslipidemia were validated as significant risk markers for DKD.
Study context
- Population
- Patients with T2D: hospital derivation cohort and community-survey external validation cohort3,556 derivation, 931 validation · hospital derivation cohort 3,556
- Comparison
- Metabolic profile clusters vs cluster 1
- Outcome
- Onset of diabetic kidney disease (DKD)
Methodological detailsderivation cohort (hospital), external validation cohort (community survey), clustering on 5 metabolic syndrome (MetS) components, multivariate adjustment for baseline covariates
- Derivation cohort (hospital)
- External validation cohort (community survey)
- Clustering on 5 MetS components
- Multivariate adjustment for baseline covariates
Performance
As reported in the abstract
DKD (derivation cohort)
Each group vs cluster 1Hazard ratio (95% CI)
Cluster 3
1.72(1.39–2.12)
Cluster 4
1.97(1.53–2.54)
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| DKD (validation cohort)Cluster 3vs Cluster 1 | aOR 1.24 (CI 1.07–1.44) | |
| DKD (validation cohort)Cluster 4vs Cluster 1 | aOR 1.39 (CI 1.03–1.87) | |
| Macroalbuminuria (derivation cohort)Cluster 3vs Cluster 1 | HR 2.74 (95% CI 1.84–4.08) | |
| Macroalbuminuria (derivation cohort)Cluster 4vs Cluster 1 | HR 2.62 (95% CI 1.61–4.25) | |
| ESRD (derivation cohort)Cluster 3vs Cluster 1 | HR 4.31 (95% CI 1.16–15.99) | |
| 0.050.21520Ratio (log scale) |
| Outcome | P value |
|---|---|
| eGFR decline (derivation cohort)Cluster 3 vs Cluster 1 · increased risk with Cluster 3 | P < 0.001 |
Original publication
Metabolic Profiles of Type 2 Diabetes and Their Association With Renal Complications. J Clin Endocrinol Metab. Published 2 November 2023. doi:10.
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