Relationship Between Average Glucose Levels and Hemoglobin A1c (HbA1c) Differs Across Racial Groups: A Substudy of the GRADE Randomized Trial
Authors' conclusion
The relationship between several measures of glucose with HbA1c and glycated albumin consistently differed across races. These findings should be considered in setting treatment goals and diagnostic levels.
Study context
- Population
- Participants of the GRADE comparative effectiveness RCT (36 US centers); 10-day continuous glucose monitoring (CGM) (AG10), then HbA1c and glycated albumin; Fasting plasma glucose (FPG) and glucose AUC from 75-g OGTTof 5,047 GRADE participants
- Participants
- 1,454 participants
- Comparison
- Relationship between AG10 and HbA1c across racial/ethnic groups
- Non-Hispanic White (NHW)n = 534reference
- Non-Hispanic Black (NHB)n = 389
- Hispanic Whiten = 327
- Othern = 204
- Primary endpoint
- Relationship between AG10 and HbA1c by racial/ethnic group
Methodological detailsmulticentre, 36 centers in the U.S.
- Multicentre
- 36 centers in the U.S.
Primary result
As reported in the abstract
Relationship between AG10 and HbA1c
HbA1c higher in NHB than NHW for AG10 100 to 250 mg/dL
0.2-0.6 percentage points
At HbA1c 7%, AG10 higher for NHW than NHB
11 mg/dL
Further findings
Relationships of FPG and AUC with HbA1c, and glucose measurements with glycated albumin
- Similar findings observed across races
Original publication
Relationship Between Average Glucose Levels and HbA1c Differs Across Racial Groups: A Substudy of the GRADE Randomized Trial. Diabetes Care. Published 23 September 2024. doi:10.
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